Jpet # 164384 -1- Neuropeptide Ff Receptors Have Opposing Modulatory Effects on Nociception

نویسندگان

  • Jelveh Lameh
  • Fabio Bertozzi
  • Nicholas Kelly
  • Paula M. Jacobi
  • Derek Nguyen
  • Abhishek Bajpai
  • Gilles Gaubert
  • Roger Olsson
  • Luis R. Gardell
چکیده

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Neuropeptide FF receptors have opposing modulatory effects on nociception.

The role of neuropeptide FF (NPFF) and its analogs in pain modulation is ambiguous. Although NPFF was first characterized as an antiopioid peptide, both antinociceptive and pronociceptive effects have been reported, depending on the route of administration. Currently, two NPFF receptors, termed FF1 and FF2, have been identified and cloned, but their roles in pain modulation remain elusive becau...

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Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents

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Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system on the supraspinal antinociceptive effects induced by the endogenous µ-opioid receptor agonists, endomorphin-1 (EM-1) and endomorphin-2 (EM-2)...

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تاریخ انتشار 2010